2024 Ctsk macrophage

Ctsk macrophage

Author: ivfi

August undefined, 2024

WebMay 18, 2012 · Other CtsK-Cre lines have also been reported that are not knock-in lines, but based on Ctsk-Cre transgenic overexpression [50, 51]. These have been used for deletion of Fcgr4 [52], Vdr [53], and ... Web4.2 M2 Macrophage Marker CD163 and CD206 are major markers for the identification of M2 macrophages [16] [17] [18].Related surface markers for M2-type cells also contain CD68. Compared with marker CD68, CD163 …

Lung macrophages utilize unique cathepsin K-dependent …

WebDec 2, 2024 · Secondary osteoporosis has been associated with cancer patients undertaking Doxorubicin (DOX) chemotherapy. However, the molecular mechanisms behind DOX-induced bone loss have not been elucidated. Molecules that can protect against the adverse effects of DOX are still a challenge in chemotherapeutic treatments. We … WebMay 19, 2024 · In humans, phagosomal CtsK activity was reduced in COPD lung macrophages and non-COPD lung macrophages exposed to cigarette smoke extract. Taken together, this study provides a comprehensive map of how peritoneal, lung and brain tissue environment shapes phagosomal composition, revealing CtsK as a key molecular … christkind postamt

Common signalling pathways in macrophage and osteoclast multinucleation ...

WebFeb 12, 2016 · Yang et al. (2013) crossed conditional Ptpn11 ( 176876) knockout (Ptpn11 (fl)) mice expressing Cre under the control of the endogenous lysozyme (LysM; 153450) … WebJun 5, 2024 · CTSK and MMP9 transcripts have also been found to be part of a macrophage multinucleation network in the rat (Kang et al., 2014). In addition, MGCs have been shown to express TRAP ( Park et al., 2012 ), suggesting that phenotypic markers of cell multinucleation are shared by MGCs and osteoclasts. WebApr 14, 2024 · Significant upregulation of several known OC genes was established in the OC group, such as CTSK, DC-STAMP, ACP5, MMP9, ATPV0D2, and ITGB3, which gives confidence in the OC-like nature of the cell culture model. In addition, several genes identified as upregulated in the OCs have genetic evidence for association with bone traits. christkind postfiliale

1513 - Gene ResultCTSK cathepsin K [ (human)]

Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK…

WebMay 7, 2024 · After knockout of Ctsk, the gene encoding Ctsk, the outcomes of Ctsk +/+ and Ctsk −/− mice were compared 24 h after rtPA-treated cerebral ischaemia with … WebApr 4, 2024 · Conditional ablation of PDGF-BB in macrophage-lineage TRAP + cells significantly reduced expression of periostin in periosteum, and an increase of PDGF-BB in Ctsk –/– mice significantly upregulated … german nato backpacksWebApr 4, 2024 · Conditional ablation of PDGF-BB in macrophage-lineage TRAP + cells significantly reduced expression of periostin in periosteum, and an increase of PDGF-BB in Ctsk –/– mice significantly upregulated periostin expression (Figure 6, A and B), suggesting that PDGF-BB induces the periosteal osteogenic microenvironment on the periosteal … christkindl wrigleyville

"WebNov 17, 2024 · Introduction. Osteoclasts originate from the monocyte/macrophage lineage and are unique multinucleated giant cells capable of bone resorption. They play … " - Ctsk macrophage

Ctsk macrophage

Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK…

WebThe activation of NFATc1, the master of osteoclastogenic transcription factor, directly regulates the induction of many osteoclastic genes, including cathepsin K (CtsK), matrix me- talloproteinase-9 (MMP-9), osteoclast-associated receptor (OSCAR), tartrate-resistant acid phosphatase (TRAP), and dendritic cell–specific transmembrane protein ... WebJul 13, 2024 · Cathepsin K (Ctsk) is a cysteine protease of the papain superfamily initially identified in differentiated osteoclasts; it plays a critical role in degrading the bone matrix. However, subsequent in vivo and in vitro studies based on animal models elucidate novel subpopulations of Ctsk-expressing cells, which display markers and properties of …

Did you know?

WebOct 1, 2001 · Cathepsin K (Ctsk) produced by osteoclasts, Cathepsin B (Ctsb) produced by septoclasts, macrophages, and osteoclasts, and immunostaining for the pan-macrophage marker F4/80 were performed (7,(51 ... WebMay 19, 2024 · In humans, phagosomal CtsK activity was reduced in COPD lung macrophages and non-COPD lung macrophages exposed to cigarette smoke extract. …

WebSep 2, 2024 · However, at 34 hphs, the motility of differentiating macrophages became reduced as they started to express ctsk:GFP, while undifferentiated macrophages remained highly mobile (Supplementary Fig. S1B; Movie S4). This suggests that the reduction of macrophage dynamics is a prerequisite for osteoclast differentiation, …

WebMar 31, 2024 · Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and ... matrix metallopeptidase 9 (MMP9) and cathepsin K (CTSK). … WebApr 5, 2024 · Importantly, receptor activator of NF-κB (RANK) ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) regulate osteoclastic differentiation and function ... Treatment with RANKL significantly increased the expression of DC-Stamp, TRAP, and Ctsk at 4 days, which was suppressed by RhoA silencing (Additional file 1: …

WebFeb 1, 2024 · Cleidocranial dysplasia is an autosomal dominant skeletal disorder resulting from RUNX2 mutations. The influence of RUNX2 mutations on osteoclastogenesis and bone resorption have not been reported. To investigate the role of RUNX2 in osteoclast, RUNX2 expression in macrophages (RAW 264.7 cells) was detected. Stable RAW 264.7 cell …

WebLung macrophages utilize unique cathepsin K-dependent phagosomal machinery to degrade intracellular collagen. Cathepsin K regulates the tumor growth and metastasis … german nato otf automatic knifeWebSep 22, 2024 · Fig. 7: High expression of CTSK is related to high enrichment of M2 macrophages of tumor-associated in CRPC. A – D IF assay analysis of the correlation … christkind puppeWebNov 17, 2024 · Introduction. Osteoclasts originate from the monocyte/macrophage lineage and are unique multinucleated giant cells capable of bone resorption. They play indispensable roles in regulating bone remodeling and maintaining bone mass [].Increased or decreased osteoclast development or function results in an imbalance between bone … christkind martin lutherWebApr 13, 2024 · The TRAP, CTSK, and MMP-9 proteins are abundantly expressed in mature osteoclasts, and involved in the osteoclast functions of the bone resorption. A murine macrophage-like cell line, RAW264 cells express RANK at high levels, and are differentiated into osteoclasts after stimulation with RANKL . christkind telefonnummerWebMar 21, 2024 · CTSK (Cathepsin K) is a Protein Coding gene. Diseases associated with CTSK include Pycnodysostosis and Nail Disorder, Nonsyndromic Congenital, 9 . Among its related pathways are Gene expression (Transcription) and Innate Immune System . Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase … christkind traditionWebSep 22, 2024 · All the genes were classified in order to clarify whether CTSK and M2 macrophages were correlated in CRPC. Before establishing the co-expression matrix withed weight, we defined the soft-threshold β as 6 in order to guarantee a scale-free topology. The degree of independence was 0.8 when the soft-threshold β reached 6 (Fig. … christkind prologWebAug 20, 2024 · Then, the pretreated macrophages were adoptively transferred into macrophage-depleted mice as shown in Fig. 2h. Results indicated that the mice transferred with S5-pretreated M1-BMDMs showed ... christkind winners history