Conditional false discovery rate
WebWe introduce a new class of methods for finite-sample false discovery rate (FDR) control in multiple testing problems with dependent test statistics where the dependence is fully or partially known. Our approach separately calibrates a data-dependent p-value rejection threshold for each hypothesis, relaxing or tightening the threshold as ... WebJul 20, 2024 · Download a PDF of the paper titled Conditional calibration for false discovery rate control under dependence, by William Fithian and Lihua Lei Download PDF …
Conditional false discovery rate
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WebOct 15, 2024 · These three methods have been shown to provide online control of the "modified" false discovery rate (mFDR) under a condition known as conditional … Based on definitions below we can define Q as the proportion of false discoveries among the discoveries (rejections of the null hypothesis): . where is the number of false discoveries and is the number of true discoveries. The false discovery rate (FDR) is then simply:
WebDec 1, 2024 · We introduce a new class of methods for finite-sample false discovery rate (FDR) control in multiple testing problems with dependent test statistics where the … WebFeb 6, 2015 · The ‘conditional false discovery rate’ (cFDR), defined as the probability that a SNP is not associated the principal phenotype given its p values for the principal and …
WebMay 28, 2024 · The false discovery rate (FDR) measures the proportion of false discoveries among a set of hypothesis tests called significant. This quantity is typically estimated based on p -values or test statistics. In some scenarios, there is additional information available that may be used to more accurately estimate the FDR. WebConditional calibration for false discovery rate control under dependence William Fithian and Lihua Lei July 17, 2024 Abstract We introduceanew classofmethodsforfinite-sample …
Webgeneralizing the false discovery rate of Banjamini and Hochberg [1]. In this article, we bring newer insight to the k-FDR considering a mixture model involving independent p-values before motivating the developments of some new procedures that control it. We prove the
WebDec 10, 2024 · A direct approach to estimating false discovery rates conditional on covariates PeerJ. 2024 Dec 10;6:e6035. doi: 10.7717/peerj.6035. eCollection 2024. … high school dreams download redditWebwhere is the number of false discoveries and is the number of true discoveries. The false discovery rate ( FDR) is then simply: [1] where is the expected value of . The goal is to keep FDR below a given threshold q. … high school dreams free download full versionhow many ceu for blsWebJun 6, 2024 · The conditional false discovery rate (cFDR) circumvents the difficulties of estimating PDFs by approximating the optimal ratio using cumulative density functions (CDFs) (Andreassen et al., 2013c). In this case, the covariate is generally a set of p-values arising from an analogous procedure on the same variables for a second ‘conditional ... high school dreams game freeWebJan 14, 2016 · $\begingroup$ Any estimate of a false discovery rate (as opposed to calculating a rate conditional on the truth of some hypothesis) must involve assumptions about the prior probabilities of hypotheses. The assumptions may be plausible for some collections of tests (say those appearing in papers published in the journals of a … how many ceu for cpr renewalWebJul 20, 2024 · We introduce a new class of methods for finite-sample false discovery rate (FDR) control in multiple testing problems with dependent test statistics where the dependence is fully or partially known. Our approach separately calibrates a data-dependent p-value rejection threshold for each hypothesis, relaxing or tightening the threshold as … high school dreams koreanWebJan 1, 2024 · Here, we used an alternative approach to address the question of genetic overlap, by applying the conditional false discovery rate (cFDR) approach. This statistical framework increases power for discovery by leveraging overlapping signal across GWAS. Importantly, cFDR analysis allows for identifying overlapping loci regardless of their ... how many ceu for bls renewal